Kisspeptin-10

What Is Kisspeptin-10?

Kisspeptin-10 (KP-10), also known as Metastin (45-54), is a synthetic peptide composed of 10 amino acids derived from the C-terminal active fragment of the larger kisspeptin-54 protein, encoded by the human KISS1 gene. As a research compound, it has attracted significant scientific interest for its potent neuroendocrine and signaling properties, extensively documented in preclinical and clinical research models.

Its underlying biological role relates to the activation of the GPR54 receptor (also known as KISS1R), a G-protein-coupled receptor central to the hypothalamic-pituitary-gonadal (HPG) axis. Studies indicate that Kisspeptin-10 stimulates gonadotropin-releasing hormone (GnRH) secretion, modulates downstream luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release, and influences metastasis suppression pathways — processes central to reproductive maturation, fertility regulation, and cellular signaling research (Kotani et al., 2001; Seminara et al., 2003).

Mechanism of Action

Kisspeptin-10 is studied for its high-affinity binding to the GPR54/KISS1R receptor, triggering Gq/11α signaling, calcium mobilization, and downstream activation of the ERK1/2 and p38 MAPK phosphorylation cascades (Ohtaki et al., 2001; Castaño et al., 2009). This signaling pathway drives GnRH neuron depolarization and modulates kisspeptin-dependent reproductive and neuroendocrine processes.

Research Use Only

Kisspeptin-10 supplied by Peptidos.eu is intended exclusively for laboratory and scientific research. It is not approved for human or animal consumption and must not be used as a medicine or diagnostic tool.

Disclaimer

The products offered by peptidos.eu are intended exclusively for research and laboratory use and are sold only to qualified professionals, institutions, or authorized entities. These products are not intended for human or veterinary consumption, nor for any application involving living organisms, including — but not limited to — diagnostic, therapeutic, or recreational purposes.

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• They are a qualified professional or entity, possessing the necessary competence, training, and facilities for the safe handling of chemical reagents;

• They will use the product in full compliance with all applicable local, national, and European Union laws and regulations;

• They will adopt appropriate safety measures during all stages of handling, storage, and disposal.

Prohibited Uses

• The product must not be used as an Active Pharmaceutical Ingredient (API) in the manufacturing or preparation of medicines intended for humans or animals;

• Any direct administration or use on humans or animals is strictly prohibited;

• Peptidos.eu does not endorse or permit the use of its products for the production, testing, or development of illegal substances.

Liability

• The purchaser assumes full responsibility for the handling, storage, and use of the product in safe conditions and in compliance with the law.

• Peptidos.eu shall not be held liable for any direct or indirect damages arising from improper use, incorrect storage, or unauthorized use of the product.

• Peptidos.eu reserves the right to refuse the sale to any individual or entity suspected of improper use of its products.

• In case of doubts regarding the safe and lawful use of the product, it is recommended to consult a qualified professional experienced in laboratory research.

Regulatory Compliance

Peptidos.eu does not claim or imply that its products are approved by the European Medicines Agency (EMA), the Food and Drug Administration (FDA), or any other regulatory authority. All information provided is for informational and scientific purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease.