AOD 9604

What Is AOD 9604?

AOD 9604 (Anti-Obesity Drug 9604) is a synthetic peptide consisting of 16 amino acids, modeled on the C-terminal fragment of human growth hormone (hGH 177–191) with an additional tyrosine residue at the N-terminus. Originally developed at Monash University in Australia, it has been investigated in preclinical and clinical research for its ability to influence lipolysis and fat oxidation independently of growth-promoting and insulin-related effects associated with full-length hGH.

Unlike intact growth hormone, AOD 9604 has been reported in research models to act on fat metabolism without raising IGF-1 levels, altering insulin sensitivity, or stimulating skeletal growth (Heffernan et al., 2001). This selective profile has made it a subject of interest in studies on obesity, metabolic regulation, and more recently, cartilage and joint repair.

Mechanism of Action

AOD 9604 is studied for its capacity to stimulate lipolysis (the breakdown of triglycerides) and inhibit lipogenesis (the formation of new fat cells), with research suggesting involvement of β3-adrenergic receptor pathways in adipocytes (Ng et al., 2000). The peptide is believed to mimic the lipolytic activity of the parent hGH molecule while bypassing its broader endocrine effects, providing a more targeted mechanism for investigating fat metabolism in research models.

Key Areas of Research

Lipolysis & Adipose Tissue Regulation

Preclinical studies in rodent models report increased fat oxidation, reduced adipose tissue mass, and improved metabolic markers following AOD 9604 administration, particularly in models of diet-induced obesity (Heffernan et al., 2001; Ng et al., 2000).

Metabolic Safety Profile

Clinical and preclinical research indicates AOD 9604 does not produce the hyperglycemic, IGF-1-elevating, or proliferative effects characteristic of intact growth hormone, supporting its use as a model compound for studying isolated lipolytic pathways (Stier et al., 2013).

Cartilage & Joint Research

Emerging studies have explored AOD 9604's potential role in chondrocyte function and cartilage matrix support, particularly in models of osteoarthritis and joint degeneration (Kwon et al., 2015).

Energy Metabolism

Investigations have examined the peptide's influence on fatty acid utilization and energy expenditure, with reports of enhanced substrate oxidation under research conditions.

Research Use Only

AOD 9604 supplied by Peptidos.eu is intended exclusively for laboratory and scientific research. It is not approved for human or animal consumption and must not be used as a medicine or diagnostic tool.

Disclaimer

The products offered by peptidos.eu are intended exclusively for research and laboratory use and are sold only to qualified professionals, institutions, or authorized entities. These products are not intended for human or veterinary consumption, nor for any application involving living organisms, including — but not limited to — diagnostic, therapeutic, or recreational purposes.

By Making a Purchase, the Customer Declares that:

• They are a qualified professional or entity, possessing the necessary competence, training, and facilities for the safe handling of chemical reagents;

• They will use the product in full compliance with all applicable local, national, and European Union laws and regulations;

• They will adopt appropriate safety measures during all stages of handling, storage, and disposal.

Prohibited Uses

• The product must not be used as an Active Pharmaceutical Ingredient (API) in the manufacturing or preparation of medicines intended for humans or animals;

• Any direct administration or use on humans or animals is strictly prohibited;

• Peptidos.eu does not endorse or permit the use of its products for the production, testing, or development of illegal substances.

Liability

• The purchaser assumes full responsibility for the handling, storage, and use of the product in safe conditions and in compliance with the law.

• Peptidos.eu shall not be held liable for any direct or indirect damages arising from improper use, incorrect storage, or unauthorized use of the product.

• Peptidos.eu reserves the right to refuse the sale to any individual or entity suspected of improper use of its products.

• In case of doubts regarding the safe and lawful use of the product, it is recommended to consult a qualified professional experienced in laboratory research.

Regulatory Compliance

Peptidos.eu does not claim or imply that its products are approved by the European Medicines Agency (EMA), the Food and Drug Administration (FDA), or any other regulatory authority. All information provided is for informational and scientific purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease.