MOTS-c

What Is MOTS-c?

MOTS-c (Mitochondrial Open Reading frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome, specifically inside the 12S rRNA gene. As a research compound, it has gained considerable scientific attention for its role as a mitochondrial-derived signaling molecule, with extensive documentation in preclinical and cellular models of metabolism, aging, and physical performance.

Its underlying biological role centers on cellular energy regulation and metabolic homeostasis. Studies indicate that MOTS-c modulates glucose metabolism, enhances insulin sensitivity, and influences the methionine-folate cycle — processes central to mitochondrial function, muscle performance, and adaptive responses to metabolic stress (Lee et al., 2015).

Mechanism of Action

MOTS-c is studied for its ability to activate AMP-activated protein kinase (AMPK), a master regulator of cellular energy balance (Lee et al., 2015). Under metabolic stress, MOTS-c translocates from the mitochondria to the nucleus, where it regulates nuclear gene expression involved in antioxidant and metabolic responses (Kim et al., 2018). Through these pathways, it supports glucose uptake, fatty acid oxidation, and mitochondrial biogenesis.

Key Areas of Research

Metabolic Regulation & Insulin Sensitivity

Preclinical models show improved insulin sensitivity, reduced diet-induced obesity, and enhanced glucose tolerance, suggesting a regulatory role in systemic metabolism (Lee et al., 2015; Cataldo et al., 2018).

Exercise Capacity & Muscle Homeostasis

Research demonstrates that circulating MOTS-c rises with exercise and that its administration improves physical performance and counteracts age-related decline in muscle function in animal models (Reynolds et al., 2021).

Aging & Longevity Research

Studies link MOTS-c to longevity-associated pathways, with declining endogenous levels observed across aging tissues. Administration in older animals has been shown to restore physical capacity and metabolic flexibility (Reynolds et al., 2021).

Bone & Adipose Tissue Research

MOTS-c has shown protective effects on bone density and adipose homeostasis, including in models of ovariectomy-induced metabolic dysfunction (Lu et al., 2019; Hu & Chen, 2018).

Pancreatic & Immune Modulation

Studies suggest MOTS-c may help preserve pancreatic β-cell integrity in autoimmune diabetes models, indicating immunomodulatory potential (Kong et al., 2018).

Research Use Only

MOTS-c supplied by Peptidos.eu is intended exclusively for laboratory and scientific research. It is not approved for human or animal consumption and must not be used as a medicine or diagnostic tool.

Disclaimer

The products offered by peptidos.eu are intended exclusively for research and laboratory use and are sold only to qualified professionals, institutions, or authorized entities. These products are not intended for human or veterinary consumption, nor for any application involving living organisms, including — but not limited to — diagnostic, therapeutic, or recreational purposes.

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• They are a qualified professional or entity, possessing the necessary competence, training, and facilities for the safe handling of chemical reagents;

• They will use the product in full compliance with all applicable local, national, and European Union laws and regulations;

• They will adopt appropriate safety measures during all stages of handling, storage, and disposal.

Prohibited Uses

• The product must not be used as an Active Pharmaceutical Ingredient (API) in the manufacturing or preparation of medicines intended for humans or animals;

• Any direct administration or use on humans or animals is strictly prohibited;

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Liability

• The purchaser assumes full responsibility for the handling, storage, and use of the product in safe conditions and in compliance with the law.

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Regulatory Compliance

Peptidos.eu does not claim or imply that its products are approved by the European Medicines Agency (EMA), the Food and Drug Administration (FDA), or any other regulatory authority. All information provided is for informational and scientific purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease.