MOTS-c

What Is MOTS-c?

MOTS-c (Mitochondrial Open Reading frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome, specifically inside the 12S rRNA gene. As a research compound, it has gained considerable scientific attention for its role as a mitochondrial-derived signaling molecule, with extensive documentation in preclinical and cellular models of metabolism, aging, and physical performance.

Its underlying biological role centers on cellular energy regulation and metabolic homeostasis. Studies indicate that MOTS-c modulates glucose metabolism, enhances insulin sensitivity, and influences the methionine-folate cycle — processes central to mitochondrial function, muscle performance, and adaptive responses to metabolic stress (Lee et al., 2015).

Mechanism of Action

MOTS-c is studied for its ability to activate AMP-activated protein kinase (AMPK), a master regulator of cellular energy balance (Lee et al., 2015). Under metabolic stress, MOTS-c translocates from the mitochondria to the nucleus, where it regulates nuclear gene expression involved in antioxidant and metabolic responses (Kim et al., 2018). Through these pathways, it supports glucose uptake, fatty acid oxidation, and mitochondrial biogenesis.

Research Use Only

MOTS-c supplied by Peptidos.eu is intended exclusively for laboratory and scientific research. It is not approved for human or animal consumption and must not be used as a medicine or diagnostic tool.

Disclaimer

The products offered by peptidos.eu are intended exclusively for research and laboratory use and are sold only to qualified professionals, institutions, or authorized entities. These products are not intended for human or veterinary consumption, nor for any application involving living organisms, including — but not limited to — diagnostic, therapeutic, or recreational purposes.

By Making a Purchase, the Customer Declares that:

• They are a qualified professional or entity, possessing the necessary competence, training, and facilities for the safe handling of chemical reagents;

• They will use the product in full compliance with all applicable local, national, and European Union laws and regulations;

• They will adopt appropriate safety measures during all stages of handling, storage, and disposal.

Prohibited Uses

• The product must not be used as an Active Pharmaceutical Ingredient (API) in the manufacturing or preparation of medicines intended for humans or animals;

• Any direct administration or use on humans or animals is strictly prohibited;

• Peptidos.eu does not endorse or permit the use of its products for the production, testing, or development of illegal substances.

Liability

• The purchaser assumes full responsibility for the handling, storage, and use of the product in safe conditions and in compliance with the law.

• Peptidos.eu shall not be held liable for any direct or indirect damages arising from improper use, incorrect storage, or unauthorized use of the product.

• Peptidos.eu reserves the right to refuse the sale to any individual or entity suspected of improper use of its products.

• In case of doubts regarding the safe and lawful use of the product, it is recommended to consult a qualified professional experienced in laboratory research.

Regulatory Compliance

Peptidos.eu does not claim or imply that its products are approved by the European Medicines Agency (EMA), the Food and Drug Administration (FDA), or any other regulatory authority. All information provided is for informational and scientific purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease.