BPC-157
Synthetic pentadecapeptide derived from a protective sequence found in human gastric juice, extensively studied for its role in tissue repair and regenerative research.
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What Is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic peptide composed of 15 amino acids, partially derived from a protective sequence naturally found in human gastric juice. As a research compound, it has attracted significant scientific interest for its cytoprotective and regenerative properties, extensively documented in preclinical animal and cellular models.
Its underlying biological role relates to maintaining gastrointestinal mucosal integrity and supporting the body's natural healing mechanisms. Studies indicate that BPC-157 promotes fibroblast proliferation, new blood vessel formation, and collagen synthesis — processes central to the repair of muscles, tendons, ligaments, and mucosal tissues (Staresinic et al., 2003).
Mechanism of Action
BPC-157 is studied for its ability to stimulate angiogenesis — the formation of new blood vessels — through activation of the VEGFR2 receptor and modulation of the Akt/eNOS signaling pathway (Chang et al., 2010; Hsieh et al., 2017). It also encourages fibroblast migration and extracellular matrix deposition, supporting faster, more structured healing.
Research Use Only
BPC-157 supplied by Peptidos.eu is intended exclusively for laboratory and scientific research. It is not approved for human or animal consumption and must not be used as a medicine or diagnostic tool.
- Chemical name
- BPC-157 (Body Protection Compound Peptide)
- Purity
- 99.782%
- Molecular formula
- C₆₂H₉₈N₁₆O₂₂
- Amino acid sequence
- Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- CAS number
- 137525-51-0
- Molecular weight
- 1419.53 g/mol
- Number of amino acids
- 15
- Appearance
- White to off-white lyophilized powder.
- Solubility / reconstitution
- Highly water-soluble. Reconstitute in bacteriostatic water; dissolves readily to a clear solution.
- Storage
- Stable for 36 months (lyophilized, 2–8°C). After reconstitution store at 4°C and use within ~2 weeks.
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- Staresinic, M., et al. (2003). Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. Journal of Orthopaedic Research, 21(6), 976–983.
- Chang, C. H., et al. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 110(3), 774–780.
- Sikirić, P., et al. (1997). Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats. Journal of Physiology-Paris, 91(3–5), 113–122.
- Hsieh, M. J., et al. (2017). Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. Journal of Molecular Medicine, 95(3), 323–333.
- Seiwerth, S., et al. (2018). BPC 157 and standard angiogenic growth factors. Gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Current Pharmaceutical Design, 24(18), 1972–1989.
- Novinscak, T., et al. (2008). Sciatic nerve recovery by pentadecapeptide BPC 157. Life Sciences, 83(5–6), 230–235.
- Vukojević, J., et al. (2018). Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157. Frontiers in Pharmacology, 9, 1326.
- Sikirić, P., et al. (2010). Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157. Current Pharmaceutical Design, 19(1), 76–83.
- Cerovecki, T., et al. (2010). Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. Journal of Orthopaedic Research, 28(9), 1155–116
- Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, 377(2), 153–159.
Disclaimer
The products offered by peptidos.eu are intended exclusively for research and laboratory use and are sold only to qualified professionals, institutions, or authorized entities. These products are not intended for human or veterinary consumption, nor for any application involving living organisms, including — but not limited to — diagnostic, therapeutic, or recreational purposes.
By Making a Purchase, the Customer Declares that:
They are a qualified professional or entity, possessing the necessary competence, training, and facilities for the safe handling of chemical reagents;
They will use the product in full compliance with all applicable local, national, and European Union laws and regulations;
They will adopt appropriate safety measures during all stages of handling, storage, and disposal.
Prohibited Uses
The product must not be used as an Active Pharmaceutical Ingredient (API) in the manufacturing or preparation of medicines intended for humans or animals;
Any direct administration or use on humans or animals is strictly prohibited;
Peptidos.eu does not endorse or permit the use of its products for the production, testing, or development of illegal substances.
Liability
The purchaser assumes full responsibility for the handling, storage, and use of the product in safe conditions and in compliance with the law.
Peptidos.eu shall not be held liable for any direct or indirect damages arising from improper use, incorrect storage, or unauthorized use of the product.
Peptidos.eu reserves the right to refuse the sale to any individual or entity suspected of improper use of its products.
In case of doubts regarding the safe and lawful use of the product, it is recommended to consult a qualified professional experienced in laboratory research.
Regulatory Compliance
Peptidos.eu does not claim or imply that its products are approved by the European Medicines Agency (EMA), the Food and Drug Administration (FDA), or any other regulatory authority. All information provided is for informational and scientific purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease.
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